Yesterday, I experienced a crash on the screen just east of Blackwater. I was moving east near the bottom of the map, just past the intersection where the road angles southwest to Loneloft. I'm running v1.5 on my Mac Pro with OSX 10.5.8. I didn't lose too much progress since I save pretty often. When I restarted the game and loaded my saved game, I skirted north around that area and didn't experience a crash. Haven't had a crash since.
In case it matters, I shutdown my computers every night to cut down on our electric bill. So my computer had not even been running a full day when the game crashed. Nor did I reboot after the crash - never even occurred to me. I just restarted the game and kept playing.
Creator of Dirk Dashing
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