Having finished with my first successful playthrough, I decided to try something. Effectively a "Vow of Poverty" monk. I'm not going to use any weapons, armor, magical rings, amulets, etc. No equippables at all, except for perhaps thrown weapons.
I tried KillingMoon's advice - at character creation, bought 5 levels of Unarmed Combat, and saved 2 skill points. When I reached level 2, I was able to get my Unarmed Combat skill to level 10... the feat REALLY turned things around in my favor. I was roflstomping Red Wolves at Level 2. Granted, I could only handle 1 at a time, maybe 2 if I was fortunate and had a healing potion, but yeah - wow - seriously.
I'm also seeing how very useful the Medicine skill is, for melee types. My last character didn't have a single rank in it, but this one has 5 at the moment - tremendous difference in HP regeneration rate.
In case you were wondering, those are actually the only two skills that my character has!

I am, however, running around and buying up other skills with coin.
If all goes well, by the time I am level 10 or so, I may be able to run around like Shroom's fighter, not eating or drinking, and since I'm not using any equipment at all, I won't have to rest and repair either.
lockjaw, I don't know if that might be a solution you're looking for, but half an hour into the game I was having a BLAST. I'd highly recommend you try it, just for kicks.
