I'm looking forward to the release of
Torchlight by Runic Games
Overgrowth by Wolfire Games
The Fool and his Money by Cliff Johnson (3 year wait so far

Machinarium by Amanita Design
Cletus Clay by Tuna Snax
DeathSpank by Hothead Games
Age of Decadence by Iron Tower Studio
Din's Curse by Soldak Entertainment
Shadows of Nightside by Flowerpot Games (MMO)